P69 pertactin: LRR, PRR and efficacious vaccine

Pertussis Vaccine Effectiveness in the Setting of Pertactin-Deficient Pertussis.

BACKGROUND In the United States, the proportion of Bordetella pertussis isolates lacking pertactin, a component of acellular pertussis vaccines, increased from 14% in 2010 to 85% in 2012. The impact on vaccine effectiveness (VE) is unknown. METHODS We conducted 2 matched case-control evaluations in Vermont to assess VE of the 5-dose diphtheria, tetanus, and acellular pertussis vaccine (DTaP) ...

Etymologia: Pertactin

Rapid Development of an Efficacious Swine Vaccine for Novel H1N1

Recombinant hemagglutinin (HA) from a novel H1N1 influenza strain was produced using an alphavirus replicon expression system. The recombinant HA vaccine was produced more rapidly than traditional vaccines, and was evaluated as a swine vaccine candidate at different doses in a challenge model utilizing the homologous influenza A/California/04/2009 (H1N1) strain. Vaccinated animals showed signif...

PRR Is Not Enough

We study the effects of wireless channel burstiness on TCP. We measure TCP throughput over single-hop link traces from MIT’s 802.11b Roofnet and Intel Berkeley’s 802.15.4 Mirage testbeds. We observe that links with the same packet reception ratio (PRR) have throughput variations of up to 320%. We find that differences in throughput are accompanied by differences in link burstiness. Using the Gi...

Accelerated Development of Vaccines

presented at the Acellular Pertussis Vaccine Confer­ence, Bethesda, MD. Mooi, F. R., et al. (1998). Polymorphism in the Bordetella pertus­sis virulence factors P69/pertactin and pertussis toxin in theNetherlands: Temporal trends and evidence for vaccine-driven evolution. Infection and Immunity, 66, 670-675. Strebel, P., et al. (2001). Population-based incidence of pertussisamong...